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Proximate mechanism of post ejaculatory refractory period after orgasm

Proximate mechanism of post-ejaculatory refractory period after orgasm and male’s need for separation from post-coital connection

The exact underlying mechanism regulating the human post-ejaculatory refractory period is not yet known. The main finding of previous research has been an occurrence of surge-like increases in plasma prolactin and oxytocin levels immediately after orgasm. However, recent advances in neuroendocrinology have resulted in the identification of a new peptide, the gonadotropin inhibitory hormone (GnIH), which is considered to inhibit the hypothalamic-pituitary-gonadal axis and sexual functions. This paper hypothesizes that GnIH causes refractoriness of the post-ejaculatory refractory period, and on the basis of studies on hormonal fluctuations at the time of orgasm, we hypothesize that in addition to its pulsatile pattern of secretion, GnIH might also exhibit a surge-like pattern of secretion.
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Farid Pazhoohi, & Mohammad Saied Salehi (2013). Effect of gonadotropin inhibitory hormone (GnIH) secretion on post-ejaculatory refractory period: A hypothesis Hypothesis DOI: 10.5779/hypothesis.v11i1.286